Researchers discover protein that may control the spread of cancer

Tuesday, February 26, 2013

Researchers at the University of Hawai'i Cancer Center have uncovered a novel mechanism that may lead to more selective ways to stop cancer cells from spreading. Associate Professor Joe W. Ramos PhD, a cancer biologist at the UH Cancer Center and his team have identified the role of the protein RSK2 in cancer cell migration, part of the process of cancer metastasis.

Cancer becomes metastatic when cells break away from the primary tumor and spread to other parts of the body. Metastatic cancer is much more difficult to treat and patients with metastatic cancer have a generally worse prognosis. "The cancers that kill are those that spread to other parts of the body or disseminate within the organ," said Ramos. "If we could keep cancer cells confined to the primary tumor mass, we could remove it with less risk of metastasis and later recurrence."

The Ramos team reports that RSK2 significantly increases cell migration in part by reducing integrin activation. Integrins play an important role in cell adhesion to their surrounding tissue and the migration of tumor cells to new locations in the body. RSK is active in both breast and prostate tumors, and promotes proliferation in these cells. It can also promote cell invasion and metastasis in head and neck cancers in addition to lung cancer and neuroblastoma.

"We focused on understanding the process of cell adhesion," said Ramos. "Integrins help the cell move by grabbing onto proteins and cells in their surroundings, pulling, then releasing and grabbing on again. Blocking a cancer cell's ability to adhere and move can control further dissemination of some metastasis. There are drugs that kill cancer cells and there are drugs that stop the division of cancer cells, but there are far fewer drugs that specifically stop the movement of cancer cells. Our work suggests that drugs that interfere with RSKs may help control or prevent metastasis."

###

The study: "RSK2 Protein Suppresses Integrin Activation and Fibronectin Matrix Assembly and Promotes Cell Migration" is published in the December 21, 2012 edition of The Journal of Biological Chemistry. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527930/

University of Hawaii Cancer Center: http://www.uhcancercenter.org/

Thanks to University of Hawaii Cancer Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 37 time(s).

Source: http://www.labspaces.net/127024/Researchers_discover_protein_that_may_control_the_spread_of_cancer

bachelorette penn state Ernie Els Teen Choice Awards 2012 Aurora victims usher James Holmes

Maine man can whistle, but he must keep moving

PORTLAND, Maine (AP) ? A man charged with disorderly conduct for his loud whistling in downtown Portland has reached a deal with the city ? he can whistle, but he can't linger in one spot.

Robert Smith, of Westbrook, has been cited by police twice in the past year after businesses complained. He pleaded guilty last summer and reached a deal with the city in which he can keep whistling as long as he's moving.

Smith maintains that his whistling ? audible a block away ? is protected free speech and usually brings smiles.

"God is showing me what I'm doing is OK," he told The Portland Press Herald (http://bit.ly/15e6AEN). "He shows me every day with laughter."

But downtown businesses have complained about the 32-year-old Smith's never-ending noise-making.

Janis Beitzer, of the Portland Downtown District, understands why some business owners are upset.

"Just like if somebody plays an instrument in front of your business or has the radio on constantly, it's irritating," Beitzer said.

Smith said he works a construction job during the summer, but when he's not working he usually takes a bus into Portland and walks downtown streets from about 9 a.m. to 5 p.m., wearing a baseball cap, wrap-around sunglasses and a backpack while listening to classic rock and oldies through his headphones.

As he walks the streets, some people laugh and smile. But others scowl or roll their eyes in disgust, making rude comments after passing by.

In a plea agreement last summer, Smith pleaded guilty to disorderly conduct and agreed to no longer whistle while standing in one place. As long as he's walking while he whistles, authorities agreed not to bother him.

The prosecutor, Trish McAllister, disagreed that Smith's whistling is protected by the First Amendment. A Portland city ordinance says whistling, hooting and other unnecessary noises that "annoy, disturb or injure the health, peace or safety of others" are forms of disorderly conduct.

"The judge and I viewed this as a behavioral issue," she said. "(Smith) was aggressive. He would follow people who gave him a wrong look."

___

Information from: Portland Press Herald, http://www.pressherald.com

Source: http://hosted2.ap.org/APDEFAULT/aa9398e6757a46fa93ed5dea7bd3729e/Article_2013-02-25-Walking%20Whistler/id-80aff390487242cfb984909908e631d9

ron white buckyballs buckyballs awake mario batali lone ranger aaron brooks

Obama to governors: 'We've got more work to do' (The Arizona Republic)

Share With Friends: | | Politics - Top Stories Stories, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/287111743?client_source=feed&format=rss

2012 groundhog day groundhog phil pee wee herman ketamine ground hogs day 2012 goundhog day punxsutawney

Libya church blast kills two Egyptians: embassy

AFP - An explosion rocked a Christian Coptic church near the western Libyan city of Misrata on Sunday, killing two people and wounding two others, all of them Egyptians, an Egyptian diplomat told AFP.

"Two Egyptians were killed and two were wounded," said the diplomat at the Egyptian embassy in Tripoli who declined to be named.

"The church explosion was in the town of Dafniya in Misrata (province). The consul went directly to Misrata to find out the details. We still don't have clear information," the diplomat said.

Earlier, a security official said one Egyptian was killed and three others were wounded in the blast at a Coptic church. The Egyptian diplomat said that one of those hurt in the explosion died later at the hospital.

Residents said the explosion took place in the early afternoon at a Coptic church in Dafniya, a Mediterranean town 30 kilometres (18.5 miles) west of Misrata, where brigades made up of former rebels hold a major checkpoint.

Source: http://www.france24.com/en/20121230-libya-church-blast-kills-two-egyptians-embassy

jan brewer independent spirit awards 2012 oscar predictions jim jones tony stewart kurt busch kurt busch

Edmonton Real Estate Market Weekly Update - Dec. 28/12

EdmontonRealEstateMarketUpdate

Here is our update on the Edmonton real estate market. (Previous week?s numbers are in brackets). For the past 7 days:

New listings: 66 (149, 190, 239)
# Sales: 87 (144, 146, 164)
Ratio: 132% (97%, 77%, 69%)
# Price changes: 23 (69, 64, 114)
# Expired/Off Market Listings: 141 (273, 143, 390)
Net loss/gain in listings this week: -162 (-268, -99, -315)
Active single family home listings: 1836 (1908, 2043, 2104)
Active condo listings: 1301 (1338, 1432,1438)
Homes 4-week running average: $401k ($400k, $392k, $390k)

Condos 4-week running average: $224k ($226k, $230k, $228k)The last weekly update of the year... If we based our weekly report on our office productivity I'd telling you the market is on fire, but the numbers show the market looks just as it should for the last week of the year. The only unusual stat is the rising average price of single family homes. The?REALTORS? Association of Edmonton is reporting 684 sales so far this month for the greater Edmonton Area, which should put us around 800 for the month (slightly below average). We'll have our monthly report on Tuesday. Best wishes for a happy new year filled with health, happiness, and spectacular success!

Edmonton real estate prices

Edmonton listings and sales

About Sara MacLennan

Sara MacLennan is the Director of Marketing at Liv Real Estate and a licensed Real Estate Associate. The bulk of Sara?s experience and wealth of expertise lies in on-line technology and marketing both for agents and consumers. Sara is the former National Director for Interactive Marketing for Coldwell Banker Canada where she was responsible for an extensive training program traveling to offices across the country training agents and brokers on marketing and technology. Find Sara on Twitter @edmontonblogger.

Source: http://edmontonrealestateblog.com/2012/12/edmonton-real-estate-market-weekly-update-dec-2812.html

Prince Harry Vegas pictures Avril Lavigne Microsoft Tropical Storm Isaac amber portwood Phyllis Diller Darla Moore

America Became Real Estate Value Leader in 2012 - TheNicheReport

?

Considering that our 2008 housing crash is held as a major lynchpin for the worldwide recession, it would seem odd to hold up our housing market as exceptionally healthy. However, it appears that a strengthening of various market foundations have turned our real estate into one of the world?s most promising property investments.

As I?d mentioned in a previous post, the burgeoning health of the American property market has not gone unnoticed by foreign financiers. In fact, Sweden?s Sovereign Wealth Fund publicly announced an upcoming purchase of $11 billion in American property holdings. This would be the investing body?s first purchase of foreign real estate, and represents an unambiguous endorsement of the growth value of American property holdings. Yngve Slyngstad, Norges Bank Investment Management chief economic officer affirmed national sentiment, stating directly, ?The U.S. is the next real estate market to invest in.?

However, despite the bullish actions of external investors, much of the strength in the American housing market has been motivated by internal factors. This year?s Q3 reports from both major lending bodies as well as financial analysts painted a newly positive picture of the housing market. The rate of mortgage defaults has dropped appreciably, and this has occurred in tandem with a rise in home closes. Ultimately, we?ve seemed to clear the fence in terms of the default wave, and many Americans who had been hesitant to seek new purchases in the post-recession are unfreezing their assets and moving en masse to settle on homes.

To return to a global perspective, new reports are emerging which point to a distinctly different outlook for real estate investing across the western world as a whole. According to a new release from Bloomberg, economic growth outlook across the EU appears to be stagnating. The U.K. in particular seems caught in a stumble, as retail and consumer spending dipped last month, an inverse trajectory from that observed in the United States. The swift return in American consumer confidence seems motivated largely by the return of the housing market. While our export sales and new business investment remained relatively stable throughout even the immediate post-crash period, the newfound strength in the housing market is co-reinforcing business development and consumer spending.

The positive macroeconomic trends in our housing market are working in dual effort with broader market gains, and are now?marshaling?consumer confidence in the domestic market. These differing market silos are cross-pollinating our market recovery, and seem to be the reason why the United States housing market has become a comparative leader. As the previously mentioned Bloomberg report outlines, the growth in the U.S. economy outstripped Commerce Department projections, growing 3.1% annually above the predicted 2.7%. The crucial housing market health metrics have all demonstrated growth this year, with turnover, home starts, and median home prices rising on a national scale.

Other economic power players have not reported similarly positive returns in FY2012. Japan continues to experience problematic rates of inflation, which has consequentially extended their national recession. However, America?s climbing volume of new building permits as well as a surge in home appliance and furniture sales indicate that momentum is maintaining across various segments of our housing market. Whether or not these indicators translate into persistent growth in FY2013 ultimately remains to be seen.

?

?

Harrison Stowe is a writer for NVR Inc., a prime developer of?new condos in Maryland. Addressing a range of real estate topics including investment, mortgages, and new construction, Stowe combines finance knowledge with additional experience working with Ryan Homes in the current real estate market.

Short URL: http://www.thenichereport.com/?p=12963

Source: http://www.thenichereport.com/articles/america-became-real-estate-value-leader-in-2012-2/

bcs game lsu vs alabama college football college football ncaa football brian van gorder blazing saddles

Best videos of 2012: Sea lice reduce pig to bones

Joanna Carver, reporter

This underwater pig feast comes in at number 5 in our best videos of 2012 countdown.

Who knew sea lice were so industrious? This time-lapse shows how they quickly devour a dead pig in an experiment probing how bodies decompose underwater. After four days, the carcass is reduced to bones before shrimp sneak in to dine on the cartilage.

The cage prevents large predators like sharks from tucking in. But it doesn't prevent an octopus from trying to access the pig's remains at the end of the clip.

Gail Anderson of Simon Fraser University in Burnaby, British Columbia, Canada, and colleagues are studying the process to see how seasonal changes and depth can affect decomposition. To find out more about the research, check out the original article, "Sea lice mob devours pig from inside out".

If you enjoyed this post, watch an elephant carcass ravaged by wild animals or a dead pig mimic how smokers decay.

Source: http://feeds.newscientist.com/c/749/f/10897/s/26f8f7a8/l/0L0Snewscientist0N0Cblogs0Cnstv0C20A120C120Cbest0Evideos0Eof0E20A120Esea0Elice0Efeast0Eon0Epig0Bhtml0Dcmpid0FRSS0QNSNS0Q20A120EGLOBAL0Qonline0Enews/story01.htm

MC Chris Colorado shooting suspect accuweather Finding Nemo 2 Provigil denver post dez bryant